Seminar: 10/17/08 - Design of Material Substrates to Modulate Cell Activity and Function

Department of Chemical Engineering
West Virginia University

Seminar

Design of Material Substrates to Modulate Cell Activity and Function

Rena Bizios
Department of Biomedical Engineering
The University of Texas at San Antonio
San Antonia, TX


ABSTRACT

Cellular and molecular events at tissue/implant interfaces dictate the fate of implants and, thus, have crucial clinical implications. Bioengineering research in this field has focused on the material side of such interfaces but, more recently, has utilized in vitro cellular/molecular models to elucidate underlying mechanisms and, subsequently, incorporate pertinent findings in the design and formulation of the next generation of biomaterials.

Design of materials to control, modulate and direct select, desired, and timely cellular/molecular responses at the tissue/implant interface has utilized information and insight provided from recent advances in various disciplines such as cellular/molecular biology, biochemistry, materials science, etc. Examples of such endeavors include: modification of material surfaces with immobilized bioactive compounds (such as select adhesive peptides); micropatterning (in order to direct and control subsequent adhesion of specific cell types in designated domains of the substrate material surface); and novel material formulations (specifically, nanoceramics and nanocomposites) with unique biocompatibility and/or improved mechanical and electrical properties. Cellular, in vitro models have been used to evaluate the cytocompatibility of these constructs and to determine the conditions needed to promote neotissue growth on such materials.

Biomaterials, which reliably and predictably promote specific interactions of biomolecules leading to targeted modulation and/or control of subsequent functions of select mammalian cells, have the potential of novel biotechnology-related applications, advances in tissue engineering and, thus, of major clinical impact.

Friday, October 17, 2008 9:30am - 10:45am
Room 401, Engineering Sciences Building
Refreshments served at 9:15 am

Questions or Directions call: 304-293-2111, ext. 2418.

10/17/2008