Statler College of Engineering and Mineral Resources
West Virginia University
395 Evansdale Drive, PO Box 6102
Morgantown, WV 26506-6102
Pulmonary drug delivery is increasingly used for both treatment of lung diseases (such as asthma and chronic obstructive pulmonary disease) and in delivering drugs to the systemic circulation. Due to complex pharmaceutical and physiological factors underlying bioavailability of inhaled drug products, computational modeling tools are urgently required to provide mechanistic insights of involved delivery processes and to estimate efficacy of pulmonary drug delivery in an accurate and efficient manner. Recently, a novel multiscale computational tool has been developed at CFD Research Corporation to simulate deposition, dissolution, absorption, transport, clearance, and actions of inhaled drug products within an integral framework of computational fluid dynamics (CFD), respiratory physiology, and physiologically based pharmacokinetic-pharmacodynamic (PBPK-PD) models. The proposed computational tool will provide a mechanism-based virtual platform to investigate interactions between drug delivery systems and physiological/pathological systems, to provide mechanistic insights into key aspects affecting efficacy and safety of inhaled drug products, and to guide optimal designs of pulmonary drug delivery systems.